Senaste besöket: Aktuellt datum och tid: lör 26 maj 2018, 08:00


Alla tidsangivelser är UTC + 1 timme [ Sommartid ]




Ny tråd Svara på tråd  [ 1 inlägg ] 
Författare Meddelande
 Inläggsrubrik: Morphological and biochemical features of Borrelia burgdorfe
InläggPostat: ons 15 jun 2016, 00:19 
Föreningsmedlem

Blev medlem: tor 18 jun 2009, 00:19
Inlägg: 1522
Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms
Leena Meriläinen,corresponding author Anni Herranen, Armin Schwarzbach, and Leona Gilbert

Abstract
The spirochaete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme disease, the most common tick-borne infection in the northern hemisphere. There is a long-standing debate regarding the role of pleomorphic forms in Lyme disease pathogenesis, while very little is known about the characteristics of these morphological variants. Here, we present a comprehensive analysis of B. burgdorferi pleomorphic formation in different culturing conditions at physiological temperature. Interestingly, human serum induced the bacterium to change its morphology to round bodies (RBs). In addition, biofilm-like colonies in suspension were found to be part of B. burgdorferi’s normal in vitro growth. Further studies provided evidence that spherical RBs had an intact and flexible cell envelope, demonstrating that they are not cell wall deficient, or degenerative as previously implied. However, the RBs displayed lower metabolic activity compared with spirochaetes. Furthermore, our results indicated that the different pleomorphic variants were distinguishable by having unique biochemical signatures. Consequently, pleomorphic B. burgdorferi should be taken into consideration as being clinically relevant and influence the development of novel diagnostics and treatment protocols.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339653/


Upp
Offline Profil  
 
Visa inlägg nyare än:  Sortera efter  
Ny tråd Svara på tråd  [ 1 inlägg ] 

Alla tidsangivelser är UTC + 1 timme [ Sommartid ]


Vilka är online

Användare som besöker denna kategori: Inga registrerade användare och 0 gäster


Du kan inte skapa nya trådar i denna kategori
Du kan inte svara på trådar i denna kategori
Du kan inte redigera dina inlägg i denna kategori
Du kan inte ta bort dina inlägg i denna kategori
Du kan inte bifoga filer i denna kategori

Hoppa till:  
cron
Powered by phpBB © 2000, 2002, 2005, 2007 phpBB Group
Theme created StylerBB.net & kodeki
Swedish translation by Peetra & phpBB Sweden © 2006-2008